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CIITA binding intervals for a classical gene within the MHC class II region and in a histone cluster 1. (A) Identification of two CIITA BIs, one proximal and other distal to the TSS of HLA-DRA. Both are CE marks and binding is associated with other constituents of the CIITA Enhanceosome (NFYA/ -YB; ATF1 and CREB1) and are positioned within DNase I hypersensitive sites. (B) Multiple CIITA BIs within a major histone cluster at chr 6p21.3.
