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. 2014 Aug 14;12:133. doi: 10.1186/s12916-014-0133-2

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© Jones et al.; licensee BioMed Central 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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IGF-1 and growth. Insulin-like growth factor-1 (IGF-1) increases during follow-up (A). Enrollment IGF-1 had negative correlations with several inflammatory markers (B, color indicates statistical significance level, + or – indicates a positive or negative correlation). This effect reduced between IGF-1 and concurrent inflammatory markers at later time points. Concentrations of IGF-1 and endotoxin correlated positively and negatively (respectively) with linear growth over the course of the study (C).