Table 2.
FVIII inhibitor screening results in Indian haemophilia A patients in the current study
| City/sending centre | Total no. of patients with bleeding disorders referred for inhibitor screening | No. of HA patients | No. of HA patients positive for FVIII inhibitors | High titre (>5 BU/ml) | Low titre (≤5 BU/ml) |
|---|---|---|---|---|---|
| West India | |||||
| Mumbai | 288 | 246 | 13 (5.28 %) | 9 (69.23 %) | 4 (30.77 %) |
| Nashik | 45 | 41 | 1 (2.44 %) | 1 (100.00 %) | 0 (0.00 %) |
| Jaipur | 129 | 100 | 4 (4.00 %) | 3 (75.00 %) | 1 (25.00 %) |
| Rajkot | 43 | 43 | 1 (2.33 %) | 0 (0.00 %) | 1 (100.00 %) |
| Surat | 98 | 71 | 3 (4.23 %) | 1 (33.33 %) | 2 (66.67 %) |
| Vadodara | 31 | 26 | 0 (0.00 %) | 0 (0.00 %) | 0 (0.00 %) |
| West-total | 634 | 527 | 22 (4.17 %) | 14 (63.64 %) | 8 (36.36 %) |
| South India | |||||
| Chennai | 86 | 81 | 17 (20.99 %) | 7 (41.18 %) | 10 (58.82 %) |
| Hyderabad | 16 | 15 | 2 (13.33 %) | 2 (100.00 %) | 0 (0.00 %) |
| Bangalore | 66 | 57 | 4 (7.02 %) | 2 (50.00 %) | 2 (50.00 %) |
| Davangere | 65 | 54 | 4 (7.41 %) | 3 (75.00 %) | 1 (25.00 %) |
| South-total | 233 | 207 | 27 (13.04 %) | 14 (51.85 %) | 13 (48.15 %) |
| North India | |||||
| Jammu | 115 | 101 | 10 (9.90 %) | 5 (50.00 %) | 5 (50.00 %) |
| Chandigarh | 29 | 26 | 1 (3.85 %) | 0 (0.00 %) | 1 (100.00 %) |
| Agra | 47 | 39 | 2 (5.13 %) | 0 (0.00 %) | 2 (100.00 %) |
| New Delhi | 29 | 23 | 0 (0.00 %) | 0 (0.00 %) | 0 (0.00 %) |
| Lucknow | 153 | 135 | 6 (4.44 %) | 2 (33.33 %) | 4 (66.67 %) |
| Varanasi | 50 | 43 | 1 (2.33 %) | 0 (0.00 %) | 1 (100.00 %) |
| North-total | 423 | 367 | 20 (5.45 %) | 7 (35.00 %) | 13 (65.00 %) |
| East India | |||||
| Kolkata | 138 | 117 | 4 (3.42 %) | 1 (25.00 %) | 3 (75.00 %) |
| Dibrugarh | 25 | 20 | 1 (5.00 %) | 0 (0.00 %) | 1 (100.00 %) |
| Guwahati | 52 | 47 | 4 (8.51 %) | 1 (25.00 %) | 3 (75.00 %) |
| East-total | 215 | 184 | 9 (4.89 %) | 2 (22.22 %) | 7 (77.78 %) |
| Total | 1,505 | 1,285 | 78 (6.07 %) | 37 (47.44 %) | 41 (52.56 %) |