Table 3.
Analysis of the treatment products given to the Indian haemophilia A patients in the study
| Region | Inhibitor status | Factor concentrates | Blood products | Factor concentrates + blood products | Total |
|---|---|---|---|---|---|
| Mumbai | Inhibitor positive | 1 (7.69 %) | 1 (7.69 %) | 11 (84.62 %) | 13 |
| Inhibitor negative | 42 (18.03 %) | 7 (3.00 %) | 184 (78.97 %) | 233 | |
| P value | 0.4757 | 0.3565 | 1.000 | ||
| Nashik | Inhibitor positive | 0 (0.00 %) | 0 (0.00 %) | 1 (100.00 %) | 1 |
| Inhibitor negative | 0 (0.00 %) | 8 (20.00 %) | 32 (80.00 %) | 40 | |
| P value | 0.000 | 1.000 | 1.000 | ||
| Jaipur | Inhibitor positive | 0 (0.00 %) | 0 (0.00 %) | 4 (100.00 %) | 4 |
| Inhibitor negative | 0 (0.00 %) | 7 (7.29 %) | 89 (92.71 %) | 96 | |
| P value | 0.000 | 1.000 | 1.000 | ||
| Rajkot | Inhibitor positive | 0 (0.00 %) | 0 (0.00 %) | 1 (100.00 %) | 1 |
| Inhibitor negative | 5 (11.91 %) | 2 (4.76 %) | 35(83.33 %) | 42 | |
| P value | 1.000 | 1.000 | 1.000 | ||
| Surat | Inhibitor positive | 0 (0.00 %) | 1 (33.33 %) | 2 (66.67 %) | 3 |
| Inhibitor negative | 3 (4.41 %) | 21(30.88 %) | 44(64.71 %) | 68 | |
| P value | 1.000 | 1.000 | 1.000 | ||
| Vadodara | Inhibitor positive | 0 (0.00 %) | 0 (0.00 %) | 0 (0.00 %) | 0 |
| Inhibitor negative | 5 (19.23 %) | 2 (7.69 %) | 19 (73.08 %) | 26 | |
| P value | NA | NA | NA | ||
| West-total | Inhibitor positive | 1 (4.55 %) | 2 (9.09 %) | 19 (86.36) | 22 |
| Inhibitor negative | 55 (10.89 %) | 47 (9.31 %) | 403 (79.80 %) | 505 | |
| P value | 0.4959 | 1.0000 | 0.5915 | ||
| Chennai | Inhibitor positive | 5 (29.41 %) | 2 (11.77 %) | 10 (58.82 %) | 17 |
| Inhibitor negative | 35 (54.69 %) | 1(1.56 %) | 28 (43.75 %) | 64 | |
| P value | 0.1004 | 0.1100 | 0.2893 | ||
| Hyderabad# | - | - | - | - | 16 |
| Bangalore# | - | - | - | - | 66 |
| Davangere# | - | - | - | - | 65 |
| South-total$ | Inhibitor positive | 5 (29.41 %) | 2 (11.77 %) | 10 (58.82 %) | 17 |
| Inhibitor negative | 35 (54.69 %) | 1 (1.56 %) | 28 (43.75 %) | ||
| 64 | |||||
| P value | 0.1004 | 0.1100 | 0.2893 | ||
| Jammu | Inhibitor positive | 0 (0.00 %) | 0 (0.00 %) | 10 (100.00 %) | 10 |
| 91 | |||||
| Inhibitor negative | 0 (0.00 %) | 2 (2.20 %) | 89 (97.80 %) | ||
| P value | 0.000 | 1.000 | 1.000 | ||
| Chandigarh | Inhibitor positive | 0 (0.00 %) | 0 (0.00 %) | 1 (100.00 %) | 1 |
| Inhibitor negative | 4 (16.00 %) | 4 (16.00 %) | 17 (68.00 %) | ||
| 25 | |||||
| P value | 1.000 | 1.000 | 1.000 | ||
| Agra | Inhibitor positive | 2 (100.00 %) | 0 (0.00 %) | 0 (0.00 %) | 2 |
| Inhibitor negative | 31 (83.78 %) | 0 (0.00 %) | 6 (16.22 %) | ||
| 37 | |||||
| P value | 1.000 | 0.000 | 1.000 | ||
| New Delhi | Inhibitor positive | 0 (0.00 %) | 0 (0.00 %) | 0 (0.00 %) | 0 |
| Inhibitor negative | 0 (0.00 %) | 0 (0.00 %) | 23(100.00 %) | ||
| 23 | |||||
| P value | NA | NA | NA | ||
| Lucknow | Inhibitor positive | 3 (50.00 %) | 0 (0.00 %) | 3 (50.00 %) | 6 |
| Inhibitor negative | 62 (48.06 %) | 0 (0.00 %) | 67 (51.94 %) | ||
| 129 | |||||
| P value | 1.000 | 0.000 | 1.000 | ||
| Varanasi | Inhibitor positive | 0 (0.00 %) | 0 (0.00 %) | 1 (100.00 %) | 1 |
| Inhibitor negative | 4 (9,52 %) | 2 (4.76 %) | 36 (85.72 %) | ||
| 42 | |||||
| P value | 1.000 | 1.000 | 1.000 | ||
| North-total | Inhibitor positive | 5 (25.00 %) | 0 (0.00 %) | 15 (75.00 %) | 20 |
| Inhibitor negative | 101 (29.11 %) | 8 (2.30 %) | 238 (68.59 %) | ||
| 347 | |||||
| P value | 0.8040 | 1.000 | 0.6279 | ||
| Kolkata | Inhibitor positive | 0 (0.00 %) | 0 (0.00 %) | 4 (100.00 %) | 4 |
| Inhibitor negative | 8 (7.08 %) | 12(10.62 %) | 93 (82.30 %) | ||
| 113 | |||||
| P value | 1.000 | 1.000 | 1.000 | ||
| Dibrugarh | Inhibitor positive | 0 (0.00 %) | 0 (0.00 %) | 1 (100.00 %) | 1 |
| 19 | |||||
| Inhibitor negative | 2 (10.53 %) | 10 (52.63 %) | 7 (36.84 %) | ||
| P value | 1.000 | 1.000 | 0.4000 | ||
| Guwahati | Inhibitor positive | 4 (100.00 %) | 0 (0.00 %) | 0 (0.00 %) | 4 |
| Inhibitor negative | 0 (0.00 %) | 0 (0.00 %) | 43 (100.00 %) | ||
| 43 | |||||
| P value | <0.0001**** | 0.000 | <0.0001**** | ||
| East-total | Inhibitor positive | 4 (44.44 %) | 0 (0.00 %) | 5 (55.56 %) | 9 |
| Inhibitor negative | 10 (5.71 %) | 22 (12.57 %) | 143 (81.72 %) | ||
| 175 | |||||
| P value | 0.0022** | 0.6024 | 0.0749 |
**P≤0.01; ****P≤0.0001
#Treatment related details were not entirely provided in the CRFs for Hyderabad, Bangalore & Davangere
$Excluding Hyderabad, Bangalore, Davangere