Table 1.
Details of karyotype results and DCDF-FISH-BCR/ABL results at presentation and on follow-up
| No | Date | Karyotype | FISH LSI-DCDF-BCR/ABL | RT-PCR | ||
|---|---|---|---|---|---|---|
| Signal pattern | Interpretation-Interphase | Interpretation-Metaphase | ||||
| Patient 1 | 3-Sep-02 | – | – | Major BCR | ||
| 10-Feb-05 | 46,XY[14] | – | – | |||
| 7-Jul-05 | 46,XY[10] | 1R2G1F (80 %) | Positive-deletion of ABL on der(9) | Fusion for BCR/ABL on der(9) | ||
| 2G2F (20 %) | Positive-Variant signal pattern | Fusion for BCR/ABL on both der(9) | ||||
| 7-Sep-06 | – | 2R2G (73 %) | Negative | – | ||
| 1R1G1F (24 %) | Positive-deletion of ABL/BCR on der(9) | |||||
| 2G2F (3 %) | Positive-Variant signal pattern | |||||
| 23-Apr-09 | 46,XY[10] | 2G2F (50 %) | Positive-Variant signal pattern | Fusion for BCR/ABL on both der(9) | ||
| 1R2G1F (28 %) | Positive-deletion of ABL on der(9) | Fusion for BCR/ABL on der(9) | ||||
| 2R2G (22 %) | Negative | Negative | ||||
| 15-Apr-10 | 46,XY[18] | 2G2F (100 %) | Positive-Variant signal pattern | Fusion for BCR/ABL on both der(9) | ||
| Patient 2 | 2-Sep-03 | 46,XY[15] | – | – | ||
| 24-Aug-04 | 46,XY[15] | |||||
| 1-Sep-06 | 46,XY[15] | 1R1G1F (100 %) | Fusion for BCR/ABL on der(9) | |||
| 24-Aug-07 | 46,XY[9] | – | ||||
| 31-Jul-09 | 46,XY[10] | 2G2F (100 %) | Fusion for BCR/ABL on both der(9) | |||