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. Author manuscript; available in PMC: 2014 Nov 25.
Published in final edited form as: Am J Psychiatry. 2010 Mar 1;167(4):418–426. doi: 10.1176/appi.ajp.2009.09060808

Figure 4. Functional connectivity analysis.

Figure 4

A. Controls demonstrate a positive correlation with activity in a left amygdala seed in ventral limbic regions, and a negative correlation in cortical regions involved in cognition. B. The negative correlation between amygdala and left parietal clusters is related to performance in controls: subjects who performed less well demonstrated diminished anti-correlation. C. Patients show increased functional connectivity between the amygdala and other limbic regions as well as increased connectivity (reduced negative correlation) with cortical regions. D. Between-groups contrast. Compared to controls, patients show significantly reduced anti-correlation between the left amygdala and the right middle frontal gyrus and right inferior parietal lobule, as well as increased connectivity between the amygdala and the right orbitofrontal cortex, right insula, and midbrain.