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. 2014 Jan 21;138(2):468–481. doi: 10.1093/toxsci/kfu015

FIG. 6.

FIG. 6.

The in vivo effects of rosiglitazone (RSG) on cardiac function and oxidative stress and influence of N-acetyl-L-cysterine (NAC) on RSG-induced changes. From (A) to (E), echocardiographic parameters collected from mice 2 h after intravenous injection of vehicle (Veh), RSG 1 and 10 mg/kg, NAC 600 mg/kg, and NAC 600 mg/kg + RSG 10 mg/kg via the tail vein. LVEDD: left ventricular end-diastolic dimension; LVESD: left ventricular end-systolic dimension; HR: heart rate; FS: fractional shortening; EF: ejection fraction. From (F) to (H), stable markers for oxidative stress (oxidative damages to lipids, proteins and DNAs in mitochondria isolated from hearts subjected to the above in vivo treatments). MDA: malondialdehyde; 8-OHdG: 8-hydroxy-2-deoxyguanosine. Data shown are mean ± SD, n = 5. *p < 0.05 versus Veh, +p < 0.05 versus RSG 10 mg/kg. Pr: protein.