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. Author manuscript; available in PMC: 2015 Dec 1.
Published in final edited form as: J Neuroimmune Pharmacol. 2014 Sep 20;9(5):615–628. doi: 10.1007/s11481-014-9566-9

Table 1.

Expression of p75NTR in cells of the immune system.

Cell type Tissue Stain intensity or
% of cells
Disease-
Associated
Increase
Reference
B Cells Blood
Muscle
Thymus
Negligible
Low
25%
Rogers et al. 2010
Colombo et al. 2012
Berzi et at. 2008
T Cells Blood
Tonsil
Muscle
Absent
Absent
Negligible
Rogers et al. 2010
Sariola 2001
Raychaudhuri et al 2011
Colombo et al. 2012
Natural Killer
Cells
Spleen
Bone Marrow
Blood
Lung
3%
3%
Absent to low
3%
IL-12 induced

IL-12, IL-2
induced
Ralainirina et al. 2010
Rogers et al. 2010
Basophils Blood Negligible
(detectable mRNA)
Burgi et al. 1996
Eosinophils Blood 10% Atopic
dermatitis
Raap et al. 2005
Mast Cells Skin 0.5% Atopic
dermatitis
Fischer et al. 2008
Monocytes/
Macrophages/
Microglia
Muscle
Spleen
Thymus
Tonsil
Blood
Low to moderate
Moderate
Absent
Absent
Low to moderate
Colombo et al. 2012
Labouyrie et al. 1997
Caroleo et al. 2001
Brain Low to moderate HIV
encephalopathy
Glioblastoma
ALS
Multiple
Sclerosis
Frontal cortical
dysplasia
Temporal Lobe
Epilepsy
Dowling et al. 1999
Neumann et al. 1998
Aronica et al. 2004
Ozbas-Gerceker et al. 2004
Macrophages/
Microglia in vitro
Moderate to strong Garaci et al. 1999
Nakakima et al. 1998
Heese et al. 1998