Table 1.
Expression of p75NTR in cells of the immune system.
Cell type | Tissue | Stain intensity or % of cells |
Disease- Associated Increase |
Reference |
---|---|---|---|---|
B Cells | Blood Muscle Thymus |
Negligible Low 25% |
Rogers et al. 2010 Colombo et al. 2012 Berzi et at. 2008 |
|
T Cells | Blood Tonsil Muscle |
Absent Absent Negligible |
Rogers et al. 2010 Sariola 2001 Raychaudhuri et al 2011 Colombo et al. 2012 |
|
Natural Killer Cells |
Spleen Bone Marrow Blood Lung |
3% 3% Absent to low 3% |
IL-12 induced IL-12, IL-2 induced |
Ralainirina et al. 2010 Rogers et al. 2010 |
Basophils | Blood | Negligible (detectable mRNA) |
Burgi et al. 1996 | |
Eosinophils | Blood | 10% | Atopic dermatitis |
Raap et al. 2005 |
Mast Cells | Skin | 0.5% | Atopic dermatitis |
Fischer et al. 2008 |
Monocytes/ Macrophages/ Microglia |
Muscle Spleen Thymus Tonsil Blood |
Low to moderate Moderate Absent Absent Low to moderate |
Colombo et al. 2012 Labouyrie et al. 1997 Caroleo et al. 2001 |
|
Brain | Low to moderate | HIV encephalopathy Glioblastoma ALS Multiple Sclerosis Frontal cortical dysplasia Temporal Lobe Epilepsy |
Dowling et al. 1999 Neumann et al. 1998 Aronica et al. 2004 Ozbas-Gerceker et al. 2004 |
|
Macrophages/ Microglia in vitro |
Moderate to strong |
Garaci et al. 1999 Nakakima et al. 1998 Heese et al. 1998 |