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. Author manuscript; available in PMC: 2015 Oct 23.
Published in final edited form as: Cell. 2014 Oct 23;159(3):487–498. doi: 10.1016/j.cell.2014.09.054

Figure 1. Common motifs in splicing networks.

Figure 1

A) Negative feedback of RNA binding proteins (RBPs) occurs when a splicing factor regulates a nonsense-mediated decay-coupled splicing event within its own transcript to repress its own protein expression and maintain steady state expression levels. B) Top panel: Positive feedback in splicing networks can occur through a double negative feedback loop. Double negative feedback results from the cross-regulation of two RBPs, producing two steady states each characterized by the exclusive expression of one of the RBPs. Bottom panel: Positive feedback also arises through composite feedback with a splicing factor (SF) and one or more transcription factors (TF) that results in a double positive feedback loop and bistability. In this case, either the SF and TF are both expressed, or the SF and TF are both off. Red hexagons indicate premature termination codons.