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. Author manuscript; available in PMC: 2015 Oct 23.
Published in final edited form as: Cell. 2014 Oct 23;159(3):487–498. doi: 10.1016/j.cell.2014.09.054

Figure 2. RNA binding protein cross-regulation in splicing networks.

Figure 2

A) Model for the cross-regulation of an autoregulatory poison exon by Rbfox2. Binding of Rbfox2 inhibits inclusion of the poison exon (red hexagon indicates premature termination codon), leading to a higher steady-state expression level of the autoregulated protein in the presence of Rbfox2. B) Rbfox2 and Ptbp2 function in a splicing cascade during neuronal differentiation. Rbfox2 directly regulates a subset of targets involved in cytoskeletal organization. In addition, inhibition of autoregulatory splicing of Ptbp2 by Rbfox2 leads to Ptbp2 upregulation. Ptbp2, either in conjunction with Rbfox2 or independently, regulates the splicing of several genes involved in adherens junction formation. Together, these primary and secondary targets of Rbfox2 contribute to the specification of neural progenitor fate (Jangi et al., 2014; Licatalosi et al., 2012).