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. Author manuscript; available in PMC: 2015 May 24.
Published in final edited form as: Nat Commun. 2014 Nov 24;5:5586. doi: 10.1038/ncomms6586

Figure 5. PF-LTP is unaffected in patDp/+ mice.

Figure 5

(a) Recording configuration. A somatic recording from a Purkinje cell (blue) is performed using a patch pipette (grey). PF burst stimulation (8 pulses at 100Hz) is applied through a stimulus electrode (orange) placed in the molecular layer. The PF burst is activated at 1Hz for 5min. (b) Typical PF-EPSCs recorded during the baseline and after application of the LTP protocol. PF-LTP is observed in wild-type mice (top) and in patDp/+ mice (bottom). (c) Time graph showing LTP at PF-Purkinje cell synapses in slices prepared from wild-type (n=9; paired Student’s t test; p=0.017) and patDp/+ mice (n=5; paired Student’s t test; p=0.02). There is no significant difference between both groups (Mann-Whitney U test; p=0.28). The arrow indicates the time point of tetanization. Error bars are mean ± SEM.