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. Author manuscript; available in PMC: 2015 May 24.
Published in final edited form as: Nat Commun. 2014 Nov 24;5:5556. doi: 10.1038/ncomms6556

Figure 6. Proposed model for BLM G4 substrate selectivity, unfolding of a G4 motif and regulation of BLM activity via binding cooperativity of RQC-HRDC domains.

Figure 6

(a) In binding to substrates containing ssDNA between G4 and duplex DNA, the HRDC domain, via its flexible linker, binds the ssDNA between G4 and the duplex region thus anchoring and stabilizing RQC interaction with G4, facilitating its unfolding. (b) ATP dependent complementary strand assisted unfolding of G4, the HRDC binds CS assisting to destabilize G4 structure.