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. 2014 Nov 25;8:152. doi: 10.3389/fncom.2014.00152

Figure 6.

Figure 6

Functional effects of feedforward inhibition in the model. (A) Raster plot of the network with feedforward inhibition inactive (left) and with feedforward inhibition active (right). MSNs are cells number 1–2744, FSIs are cells 2745–2888. MSNs are responding to noisy, unstructured input, while FSIs are completely synchronized and bursting every 125 ms. (B) Histogram of the 2744 MSNs aligned to the beginning of the FSI bursts. With FSIs completely synchronized, feedforward inhibition only mildly suppresses MSN spiking. Arrows and vertical black lines indicate FSI spikes. (C) Raster plot of network with feedforward inhibition inactive (left) and with feedforward inhibition active (right). In this simulation, MSNs 1–1372 are responding to structured input, while MSNs 1373–2744 are responding to unstructured input. FSIs are desynchronized and are responding with a mean spike rate of 60 Hz. (D) Left, histogram of non-ensemble cells (MSNs 1373–2744) aligned to each ensemble spike in cells 1–1372. Comparing the case with feedforward inhibition inactive (gray histogram) to the case with feedforward inhibition active (red histogram), it is clear that feedforward inhibition can significantly suppress non-coordinated MSN spiking. Right, histogram of the ensemble cells (MSNs 1–1372) aligned to each ensemble spike. Comparing the case with feedforward inhibition inactive (gray histogram) to the case with feedforward inhibition active (red histogram), it is clear that feedforward inhibition suppresses but does not eliminate coordinated MSN spiking. Accordingly, feedforward inhibition suppresses both coordinated and uncoordinated MSN spiking, though it is unable to completely suppress either type of activity.