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Changes in DNA of germinal and somatic cells. SNVs in germinal cells, present in the zygote, will result in the appearance of these SNVs in all the cells of the organism. Changes resulting in SNVs at earlier developmental stages will be present in more cells than those occurring in late adulthood. Late somatic mutations in brain cells may promote specific changes in DNA. These changes may cause the appearance of neurodegenerative disorders.
