Table 3.

Association between syndemic factors and HIV incidence

	Unadjusted Models1		Multivariable Models2
	OR (95% CI)	P-value	aOR (95% CI)	P-value
Major depressive disorder	1.44 (1.15 to 1.81)	0.002	1.19 (0.94 to 1.51)	0.15
Substance use disorder	5.79 (4.99 to 6.73)	<0.001	3.71 (3.12 to 4.40)	<0.001
Alcohol use disorder	1.68 (1.47 to 1.92)	<0.001	1.31 (1.16 to 1.47)	<0.001
Intimate partner violence	2.93 (2.22 to 3.86)	<0.001	2.28 (1.64 to 3.18)	<0.001
Additive syndemic factors	1.73 (1.56 to 1.93)	<0.001	1.46 (1.30 to 1.65)	<0.001
Restricted to Women Only
Major depressive disorder	1.64 (1.29 to 2.10)	<0.001	1.60 (1.22 to 2.09)	0.001
Substance use disorder	**		**
Alcohol use disorder	1.01 (0.82 to 1.24)	0.95	1.00 (0.78 to 1.27)	0.97
Intimate partner violence	3.81 (2.11 to 6.86)	<0.001	2.32 (1.18 to 4.55)	0.015
Additive syndemic factors	1.62 (1.28 to 2.04)	<0.001	1.47 (1.11 to 1.95)	0.008
Restricted to Men Only
Major depressive disorder	1.44 (0.89 to 2.33)	0.13	0.93 (0.57 to 1.52)	0.78
Substance use disorder	7.85 (6.52 to 9.44)	<0.001	4.27 (3.35 to 4.45)	<0.001
Alcohol use disorder	1.72 (1.49 to 1.98)	<0.001	1.44 (1.29 to 1.61)	<0.001
Intimate partner violence	2.32 (2.05 to 2.63)	<0.001	2.33 (1.87 to 2.89)	<0.001
Additive syndemic factors	1.76 (1.60 to 1.94)	<0.001	1.49 (1.32 to 1.68)	<0.001

^**No women with substance use disorder had a newly diagnosed HIV infection;

¹Survey-weighted bivariate logistic regression models;

²Survey-weighted multivariable logistic regression models adjusting for age, sex, sexual identity, race/ethnicity, urbanicity, and education