Table 1.

Host proteins relevant in ubiquitin-mediated response to Salmonella infection.

Host protein	Function	Physiological effect	Reference
OPTN	Contains ubiquitin-binding domain; autophagy receptor	Selective autophagy of ubiquitin-coated Salmonella	(18)
p62	Autophagy receptor	Autophagy of ubiquitin-coated Salmonella	(15, 16)
NDP52	Autophagy receptor	Autophagy of ubiquitin-coated Salmonella	(14)
LRSAM1	RING-type E3 ligase	Restriction of bacterial replication, required for autophagy of Salmonella	(19)
USP18	ISG15-specific deubiquitinase	Regulation of inflammatory response to Salmonella, IFN signaling	(25)
UCH-L1	Deubiquitinase	Increase in bacterial uptake, remodeling of actin cytoskeleton	(26)
HsRMA1	E3 ligase	Ubiquitination of bacterial SopA, induces bacterial escape to cytosol from SCV	(28)
UbcH5c	E2 enzyme	SopB localization to SCV, works with TRAF6	(29)
TRAF6	RING-type E3 ligase	Ubiquitination of bacterial effector SopB, downregulation of SopB activity and its localization in SCV	(29–31)
TRIM21	E3 ligase	Recognition of intracellular antibodies during infection	(27)