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. Author manuscript; available in PMC: 2014 Nov 25.
Published in final edited form as: Eur J Pharm Biopharm. 2013 Dec 19;86(3):514–523. doi: 10.1016/j.ejpb.2013.12.009

Table 6.

Cell growth inhibition in AsPC-1 cells (mean ± SD, n = 3–6).

Prodrug/drug GI50 AsPC-1 (mM)
Gemcitabine 10.2 ± 1.6
5′-L-Phenylalanyl-gemcitabine 4.3 ± 1.5*
5′-D-Phenylalanyl-gemcitabine 5.6 ± 1.1*
5′-L-Valyl-gemcitabine 2.0 ± 0.8*
5′-D-Valyl-gemcitabine 2.2 ± 0.9*
*

p < 0.05, Compared with gemcitabine.