Table 1.
Quantification of organoid-forming progenitors in phenotypically defined pancreatic cell subpopulations.
Organ | Population | Organoids per 1000 input cells | SD | Single-cell deposition | |
---|---|---|---|---|---|
Pancreas | CD45/11b/31+ | Blood/endothelium | <1 | na | |
CD45−11b−31− | Non-blood/endothelium | 4 | 2 | ||
CD45−11b−31−MIC1-1C3+ | Duct cells | 31 | 13 | ||
CD45−11b−31−MIC1-1C3− | Non-duct cells | 2.7 | 2 | ||
CD45−11b−31−MIC1-1C3+CD26+ | Progenitor-depleted duct cells | <1 | na | ||
CD45−11b−31−MIC1-1C3+133+26− | Progenitor-enriched duct cells | 44.6 | 14 | 1 in 19.7 | |
Liver | CD45/11b/31+ | Blood/endothelium | <1 | na | |
CD45−11b−31− | Non-blood/endothelium | 3.3 | 3 | ||
CD45−11b−31−MIC1-1C3+CD26+ | Progenitor-depleted duct cells | 1.1 | 2 | ||
CD45−11b−31−MIC1-1C3+133+26− | Progenitor-enriched duct cells | 38.5 | 11 | 1 in 17.4 |