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. Author manuscript; available in PMC: 2014 Nov 25.
Published in final edited form as: Chem Biol. 2013 Sep 12;20(10):1245–1254. doi: 10.1016/j.chembiol.2013.07.017

Figure 2. Synthesis of the Acetylene Spacer Analogs and the Brominated Analog of 1.

Figure 2

(A) Synthesis of acetylene spacer analogs 18a, 18b, and 18c. The intermediates 17a, 17b, and 17c, with bromine (Br) residues at position 6 were also hydrolyzed and tested for biological activity.

(B) Bromination of 1 to obtain compound 20.

See also Table S2.