Table 2.
Surgery and chemotherapy outcomes in 31 patients with predominant plasmacytoid histology
| No. Pts (%) | |
|---|---|
| Surgery type: | |
| No surgery | 9 (29) |
| Cystectomy/cystoprostatectomy | 17 (55) |
| Exenteration | 2 (6) |
| Transurethral bladder tumor resection | 2 (6) |
| Surgery aborted due to T4b stage | 3 (10) |
| Unknown | 1 (3) |
| Lymph node dissection: | |
| Yes | 20 (65) |
| No | 9 (29) |
| Unknown | 2 (6) |
| Lymph node status at surgery: | |
| Pos | 11 (35) |
| Neg | 9 (29) |
| Not applicable (no surgery or no lymph node dissection) | 10 (32) |
| Unknown | 1 (3) |
| Margin status at surgery: | |
| Pos | 2 (6) |
| Neg | 18 (58) |
| Not applicable (no surgery or unreported margins) | 10 (32) |
| Unknown | 1 (3) |
| Pathological CR: | |
| Yes | 4 (13) |
| No | 17 (55) |
| Not applicable (no or aborted surgery) | 9 (29) |
| Unknown | 1 (3) |
| Chemotherapy setting: | |
| None | 3 (10) |
| Neoadjuvant | 7 (23) |
| Adjuvant | 7 (23) |
| Metastatic | 14 (45) |
| Best chemotherapy response: | |
| CR (tumor resolution on imaging) | 6 (19) |
| Less than CR on imaging | 10 (32) |
| Stable disease | 1 (3) |
| Progressive disease | 1 (3) |
| Unknown | 2 (6) |
| Not applicable (adjuvant or no chemotherapy) | 11 (35) |
| Chemotherapy type:* | |
| Dose dense MVAC | 14 (45) |
| Ifosfamide, doxorubicin + gemcitabine | 8 (26) |
| GC based | 6 (19) |
| Other | 6 (19) |
| Unknown | 1 (3) |
| None | 3 (10) |
| Post-chemotherapy progression site:† | |
| Peritoneum | 19 (61) |
| Retroperitoneal lymph nodes | 3 (10) |
| Bladder | 3 (10) |
| Bone, lungs, scrotum | 3 (10) |
| Unknown | 3 (10) |
| No progression | 5 (16) |
CR plus partial response in 7 of 9 patients with dose dense MVAC, 6 of 7 (86%) with ifosfamide, doxorubicin and gemcitabine, all 5 (100%) with GC based chemotherapy and 3 of 4 (75%) with other chemotherapy, not including those with adjuvant chemotherapy or missing response data and with percents totaling greater than 100% since some patients received more than 1 regimen.
Some patients had progression at different sites.