Table 2.
No. Pts (%) | |
---|---|
Surgery type: | |
No surgery | 9 (29) |
Cystectomy/cystoprostatectomy | 17 (55) |
Exenteration | 2 (6) |
Transurethral bladder tumor resection | 2 (6) |
Surgery aborted due to T4b stage | 3 (10) |
Unknown | 1 (3) |
Lymph node dissection: | |
Yes | 20 (65) |
No | 9 (29) |
Unknown | 2 (6) |
Lymph node status at surgery: | |
Pos | 11 (35) |
Neg | 9 (29) |
Not applicable (no surgery or no lymph node dissection) | 10 (32) |
Unknown | 1 (3) |
Margin status at surgery: | |
Pos | 2 (6) |
Neg | 18 (58) |
Not applicable (no surgery or unreported margins) | 10 (32) |
Unknown | 1 (3) |
Pathological CR: | |
Yes | 4 (13) |
No | 17 (55) |
Not applicable (no or aborted surgery) | 9 (29) |
Unknown | 1 (3) |
Chemotherapy setting: | |
None | 3 (10) |
Neoadjuvant | 7 (23) |
Adjuvant | 7 (23) |
Metastatic | 14 (45) |
Best chemotherapy response: | |
CR (tumor resolution on imaging) | 6 (19) |
Less than CR on imaging | 10 (32) |
Stable disease | 1 (3) |
Progressive disease | 1 (3) |
Unknown | 2 (6) |
Not applicable (adjuvant or no chemotherapy) | 11 (35) |
Chemotherapy type:* | |
Dose dense MVAC | 14 (45) |
Ifosfamide, doxorubicin + gemcitabine | 8 (26) |
GC based | 6 (19) |
Other | 6 (19) |
Unknown | 1 (3) |
None | 3 (10) |
Post-chemotherapy progression site:† | |
Peritoneum | 19 (61) |
Retroperitoneal lymph nodes | 3 (10) |
Bladder | 3 (10) |
Bone, lungs, scrotum | 3 (10) |
Unknown | 3 (10) |
No progression | 5 (16) |
CR plus partial response in 7 of 9 patients with dose dense MVAC, 6 of 7 (86%) with ifosfamide, doxorubicin and gemcitabine, all 5 (100%) with GC based chemotherapy and 3 of 4 (75%) with other chemotherapy, not including those with adjuvant chemotherapy or missing response data and with percents totaling greater than 100% since some patients received more than 1 regimen.
Some patients had progression at different sites.