Table 1.
Contractile properties of isolated coronary arteries from sham-, IR- or PI-operated rats
| Surgery | Segment | Endothelin-1 | Endothelin-1 +desensitization +BQ788 (30 nM) | Endothelin-1 +BQ788 (0.9 μM) | Endothelin-1 +BQ123 (10 μM) | S6c | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Emax | pEC50 | Emax | pEC50 | Emax | pEC50 | Emax | pEC50 | Emax | pEC50 | ||
| Sham | Upstream | 91.1 ± 4.0 | 9.2 ± 0.1 | 80.6 ± 3.3 | 9.2 ± 0.1 | – | – | – | – | 11.9±4.6 | 9.3 ± 0.5 |
| Downstream | 89.8 ± 5.0 | 9.0 ± 0.1 | 83.6 ± 5.8 | 9.4 ± 0.1 | 95.2 ± 3.8 | 9.2 ± 0.1 | 86.8 ± 13.5 | 7.8 ± 0.2 | 0.8 ± 3.6 | ND | |
| SCA | 92.7 ± 4.8 | 9.0 ± 0.1 | 86.8 ± 4.4 | 9.1 ± 0.1 | – | – | – | – | 4.5 ± 1.5 | ND | |
| IR | Upstream | 89.0 ± 4.8 | 9.2 ± 0.1 | 86.3 ± 6.5 | 9.3 ± 0.1 | – | – | – | – | 13.9 ± 4.3 | 9.4 ± 0.4 |
| Downstream | 102.4 ± 8.7 | 10.0 ± 0.1 | 89.6 ± 6.0 | 9.4 ± 0.1 | 99.6 ± 4.1 | 9.0 ± 0.1 | 96.8 ± 10.1 | 8.6 ± 0.2 | 52.3 ± 10.0 | 10.0 ± 0.3 | |
| SCA | 101.3 ± 8.7 | 9.3 ± 0.1 | 89.5 ± 6.2 | 9.4 ± 0.1 | – | – | – | – | ND | ND | |
| PI | Upstream | – | – | 85.7 ± 6.9 | 8.8 ± 0.2 | – | – | – | – | 14.1 ± 3.1 | 9.2 ± 0.7 |
| SCA | – | – | 83.5 ± 5.3 | 9.2 ± 0.1 | – | – | – | – | 4.8 ± 2.7 | ND | |