TABLE 2.
Histology and Molecular Pathology of Lung Lesions
| Patient No. | Histopathology | EGFR | KRAS |
|---|---|---|---|
| 1 | Metastatic Wilms’ tumor | n/a | n/a |
| Bronchioloalveolar carcinomaa (2 foci of 0.1 cm each) | |||
| 2 | Bronchioloalveolar carcinoma (<0.5 cm) | n/a | n/a |
| 3 | Solitary focus of bronchioloalveolar carcinoma (0.25 cm) | Negative | Negative |
| Multiple foci of benign metaplastic ossification in lung | |||
| 4 | Bronchioloalveolar carcinoma (0.26 cm) | Negative | Negative |
| 5 | Well-differentiated, acinar-type adenocarcinoma (0.6 cm) | L858R mutation | Negative |
| 6 | Moderately differentiated adenocarcinoma, mixed subtype, with acinar and nonmucinous bronchioloalveolar patterns (0.5 cm) | Negative | Negative |
| Adenocarcinoma, acinar subtype (0.3 cm) | |||
| Metastatic osteosarcoma (0.15 cm) | |||
| 7 | Adenocarcinoma, mixed subtype with papillary and bronchioloalveolar patterns (0.2 cm) | Negative | G12V mutation in adenocarcinoma |
| Bronchioloalveolar carcinoma (0.2 cm) | |||
| Metastatic mesenchymal chondrosarcoma (0.6 cm) | |||
| 8 | Moderately differentiated adenocarcinoma, mixed subtype, predominantly acinar and papillary (2.0 cm) | Exon 19 deletion in adenocarcinoma | Not done |
| Metastatic osteosarcoma (0.3 cm) |
a
Bronchioloalveolar carcinoma is currently called adenocarcinoma in situ in the new classification.32
n/a, specimen insufficient or unavailable for molecular study.