Table 2.

Mean (± SD) brain histamine H₁-receptor occupancy values (%) for bilastine and hydroxyzine in 12 healthy volunteers

Receptor occupancy (%)
Region of interest	Bilastine 20 mg (*)	Hydroxyzine 25 mg
Frontal	−2.41 ± 20.97	58.91 ± 13.37
Occipital	−8.07 ± 19.60	56.96 ± 21.95
Parietal	−7.17 ± 20.74	49.93 ± 12.29
Temporal	0.38 ± 12.61	62.83 ± 20.60
Insula	−2.32 ± 11.83	41.12 ± 11.10
Total	−3.92 ± 14.39	53.95 ± 14.13
Mean difference and 95% CI bilastine vs. hydroxyzine Median difference and 95% CI bilastine vs. hydroxyzine	57.870% (42.664%, 73.075%) 54.228% (43.713%, 78.819%)

^*P < 0.01 vs. hydroxyzine.