Table 1.

Overview of study design with six different strata of administration sequence

	Sequence 1	Sequence 2	Sequence 3	Sequence 4	Sequence 5	Sequence 6
Period 1	Sublingual	Sublingual	Oral	Oral	Rectal	Rectal
Period 2	Rectal	Oral	Sublingual	Rectal	Sublingual	Oral
Period 3	Oral	Rectal	Rectal	Sublingual	Oral	Sublingual