Table 2.
Parameter estimates
| Parameter | Estimate (95% CI) | % RSE |
|---|---|---|
| CLinduced/F (l h−1) | 54.9 (42.5, 67.2) | 11.7 |
| ΔCL/F (l h−1) | 30.1 (14.8, 45.4) | 27.6 |
| Vd/F (l) | 53.8 (38.4, 69.1) | 14.9 |
| Ka (h−1) | 0.172 (0.141, 0.203) | 9.2 |
| Alag (h) | 0.178 (0.136, 0.220) | 11.7 |
| Kinduct (h−1) | 0.023 (fixed)* | – |
| Interindividual variability | % CV | % RSE |
| IIV for CLinduced/F | 22.8 | 36.7 |
| IIV for Vd/F | 84.4 | 20.3 |
| IIV for Ka | 35.4 | 24.1 |
| IIV for Alag | 137.1 | 76.1 |
| Residual variability | Variance | % RSE |
| σ2additive | 0.596 | 17.8 |
| Secondary parameters | Median (range) | % RSE |
| CLinitial/F (l h−1) | 23.6 (9.6–45.5) | – |
| AUCinitial (mg h l−1) | 52.9 (27.5–129.7) | – |
| AUCinduced (mg h l−1) | 23.3 (16.5–31.4) | – |
CL/F = CLinduced/F − ΔCL/F × exp(−Kinduct × t). CLinitial/F = CLinduced/F − ΔCL/F. The 95th percentile confidence intervals (CIs) and relative standard error (RSE) estimates were derived from bootstrap analysis.
*
Kinduct was fixed at 0.023 due to the fact that maximal clearance induction was reached on day 7.
CI, confidence interval; CV, coefficient of variation; IIV, inter-individual variability; RSE, relative standard error.