Table 1.

Characteristics at inclusion or at time of PK sample collection (fourth dose) of the 51 ICU patients included in the PK analysis

Parameters	Value*
At inclusion
Male	41 (80%)
Age (years)	60 [28–84]
Total bodyweight (kg)	77 [45–126]
SAPS II	40 [19–74]
At time of fourth dose
Weight change (kg)†	1.1 [−18.1–19.1]
SOFA	6 [2–14]
Oedema score	7 [0–18]
Serum albumin (g l−1)‡	18 [10–28]
CrCL4h (ml min−1)	86.4 [9.1–571.4]
Shock	18 (35%)
PEEP (cmH2O)	6 [0–13]
	182 [81–346]

Abbreviations are as follows: ICU, intensive care unit; PEEP, positive end-expiratory pressure; PK, pharmacokinetics.

^*Values are expressed as median [min–max] or number (percentage).

^†Between the fourth dose and admission.

^‡Median value for nine patients.