Table 3.
Geometric mean ratios and 90% confidence intervals (CI) of Cmax and AUCτ comparing treatment C with treatments A (macitentan and ACT-132577) and B (sildenafil and N-desmethylsildenafil) (n = 12)
| Variable | Lower 90% CI | Geometric mean ratio (treatment C : A) | Upper 90% CI |
|---|---|---|---|
| Macitentan | |||
| Cmax | 0.92 | 0.99 | 1.06 |
| AUCτ | 1.01 | 1.06 | 1.12 |
| ACT-132577 | |||
| Cmax | 0.76 | 0.82 | 0.89 |
| AUCτ | 0.80 | 0.85 | 0.91 |
| Variable | Lower 90% CI | Geometric mean ratio (treatment C : B) | Upper 90% CI |
| Sildenafil | |||
| Cmax | 1.07 | 1.26 | 1.48 |
| AUCτ | 0.94 | 1.15 | 1.41 |
| N-desmethylsildenafil | |||
| Cmax | 0.99 | 1.10 | 1.22 |
| AUCτ | 0.96 | 1.08 | 1.22 |