Table 2.
Population pharmacokinetics parameters of 25(OH)D
| Parameter | Estimate (RSE %) |
|---|---|
| Structural model | |
| CL/F (l day−1) | 0.96 (13) |
| V/F (l) | 71.3 (3) |
| C0 (ng ml−1)† | 14.7 (8) |
| θNo white | 0.74 (9) |
| θBW | −0.29 (38) |
| Statistical model | |
| ω BSV CL/F | 0.46 (32) |
| ω BSV C0 | 0.39 (9) |
| σ proportional | 0.20 (11) |
†
C0 = C0*(θNo white)*(BW/median(BW))*∧θBW. For example, for a non-white patient weighing 40 kg, individual C0 is 14.7*.74*(40/50)∧ − 0.29 = 11.6 ng ml−1. RSE%, relative standard error (standard error of estimate/estimate*100); CL/F, apparent elimination clearance; V/F, apparent central volume of distribution; C0, basal 25(OH)D concentration; σ, residual variability estimates and BSV, between subject variability estimates; θNo white, influential factor on 25(OH)D C0 for a non-white skin phototype patient; θBW, influential factor on 25(OH)D C0 for bodyweight.