Table 3.
Statistical analysis for midazolam pharmacokinetics
| Probe | Comparison | GMR (90% CI) | ||
|---|---|---|---|---|
| AUC(0,∞) | AUC(0,t) | Cmax | ||
| Ketoconazole | MDZi.v. + KETO vs. MDZi.v. | 5.16 (4.063, 6.556) | 3.45 (2.873, 4.145) | 1.16 (1.021, 1.307) |
| MDZoral + KETO vs. MDZoral | 11.53 (9.936, 13.380) | 8.34 (7.243, 9.612) | 3.74 (3.165, 4.423) | |
| Rifampin | MDZi.v. + RIF vs. MDZi.v. | 0.49 (0.406, 0.588) | 0.50 (0.413, 0.594) | 0.90 (0.714, 1.128) |
| MDZoral + RIF vs. MDZoral | 0.08 (0.059, 0.101) | 0.07 (0.054, 0.083) | 0.11 (0.104, 0.126) | |
| Placebo | MDZi.v. + PBO vs. MDZi.v. | 0.95 (0.903, 1.002) | 0.96 (0.915, 1.015) | 0.96 (0.891, 1.041) |
| MDZoral + PBO vs. MDZoral | 1.04 (0.933, 1.167) | 1.04 (0.935, 1.155) | 1.05 (0.878, 1.259) | |
MDZi.v. = 0.4 mg single dose i.v.; MDZoral = MDZ 2 mg single dose orally; KETO = ketoconazole 400 mg once daily for 14 days; RIF = rifampicin 600 mg once daily for 14 days; PBO = placebo once daily for 14 days. CI, confidence interval; GMR, ratio of geometric least-squares means.