Table 1.
Redox signalling pathways in mouse models of neurodegenerative diseases
| Strain | Model | Signalling pathways examined | Reference |
|---|---|---|---|
| SAMP8 | Ageing | MDA, NO, GPx | 146 |
| C57Bl/6N Sim | Ageing | MDA, 8-OHdG | 72 |
| C57Bl/6 | HFLD | Protein carbonyl | 79 |
| SAMP8 | Ageing | Protein carbonyl, TBARS | 147 |
| C57Bl/6N Sim | Ageing | Protein carbonyl, MDA | 148 |
| Balb/C | Ageing | GSH | 149 |
| FVB/N | Tg2576 | 8,12-iso-iPF2α-VI | 150 |
| C57BL/6J | LPS | TNFα, IL-1β, Iba-1, MCP-1 | 132 |
| C57BL/6J | MPTP | iNOS, 3-NT, 4-HNE | 151 |
| C57BL/6J | MPTP | MAC-1, Iba-1, ED-1, 8-OHdG, 3-NT, iNOS, MPO | 134 |
| C57BL/6J | LPS | TNFα, IL-6, KC, IL-12, NO, nitrite, p-p38 | 143 |
| C57BL/6J | MPTP | MAC-1, iNOS, TNFα | 143 |
| C57BL/6J | MPTP | iNOS, IL-1β, TNFα, CD11b, GFAP, NF-κB | 152 |
| C57BL/6J | MPTP | ASK1, p-MKK4, p-JNK, GSH, Daxx, DJ-1 | 142 |
| C57BL/6J | MPTP | 4-HNE, 3-NT, GSH, GSSG | 135 |
| C57BL/6J | MPTP | Nitrite | 131 |
| C57BL/6J | MPTP | MAC-1, protein carbonyl | 133 |
| C57BL/6 | MPTP | Bax, p53 | 145 |
| C57BL/6J | MPTP | p-JNK, p-MKK4 | 141 |
3-NT, 3-nitrotyrosine; 4-HNE, 4-hydroxynonenal; 8,12-iso-iPF2α-VI, isoprostane; 8-OHdG, 8-Hydroxy-2′-deoxyguanosine; ASK1, apoptosis signal-regulating kinase 1; Bax, Bcl-2-associated X protein; CD11b, cluster of differentiation molecule 11b; Daxx, death-associated protein; DJ-1, Parkinson’s disease protein; ED-1, clone ED1 CD68 microglial/macrophage marker; GFAP, glial fibrillary acidic protein; GPx, glutathione peroxidise; GSH, glutathione; GSSG, oxidized glutathione; HFLD, high fat lard diet; Iba-1, ionized calcium binding adapter molecule 1; IL-1β, interleukin-1 beta; IL-6, interleukin-6; IL-12, interleukin-12; iNOS, inducible nitric oxide synthase; KC, keratinocyte-derived chemokine; LPS, lipopolysaccharide; MAC-1, macrophage antigen complex-1; MCP-1, monocyte chemoattractant protein-1; MDA, malondialdehyde; MPO, myeloperoxidase; MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; NFκB, nuclear factor kappa B; NO, nitric oxide; p-MKK4, phospho-dual specificity mitogen-activated protein kinase kinase 4; p-JNK, phospho-c-jun N-terminal kinase; p-p38, phospho-p38 mitogen-activated protein kinase; p53, tumour suppressor protein; TBARS, thiobarbituric acid reactive substance; Tg2576, mouse model of Alzheimer’s disease amyloidosis; TNFα, tumour necrosis factor alpha.