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| Female gender |
| Hypothyroidism |
| Viral infections |
| Advanced age (>80 years of age in particular) |
| Small body frame and frailty |
| Multisystem disease (e.g. chronic renal insufficiency, especially due to diabetes mellitus) |
| Hepatic disorders |
| Peri-operative periods |
| Injuries |
| Alcohol abuse |
| Polypharmacotherapy |
| Specific concomitant medications (see Table 4) |
| Physical exertion |
