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(A) Individual plasma trametinib and [14C]-trametinib concentration vs. time profiles after oral (2 mg) and i.v. (5 μg) administration. Individual patients are denoted by symbols and colours. The dashed lines represent oral trametinib; the solid lines represent i.v. [14C]-trametinib. Inset shows detail from 0 to 24 h post-dose
