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Mean plasma [14C]-trametinib (solid line, ng ml−1) and total radioactivity (dashed line, ng equivalents of trametinib ml−1) concentration vs. time profile after i.v.; 5 μg administration (n = 4). Inset shows detail from 0 to 24 h post-dose. 
, [14C]-trametinib; 
, total radioactivity
