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. 2014 Aug 21;78(3):556–564. doi: 10.1111/bcp.12368

Figure 2.

Figure 2

Mean changes in pupil diameter over time after loperamide administration. Plots are separately drawn for all doses (A) or each dose of HM30181 (15, 60 and 180 mg in B, C and D, respectively). *P < 0.05 between loperamide plus quinidine vs. loperamide plus HM30181, +P < 0.05 between loperamide plus quinidine vs. loperamide alone and ∧P < 0.05 between loperamide plus HM30181 vs. loperamide alone. A) Inline graphic, loperamide alone; Inline graphic, quinidine + loperamide; Inline graphic, HM30181 + loperamide; B) Inline graphic, loperamide alone; Inline graphic, quinidine + loperamide; Inline graphic, HM30181 15 mg + loperamide; C) Inline graphic, loperamide alone; Inline graphic, quinidine + loperamide; Inline graphic, HM30181 60 mg + loperamide; D) Inline graphic, loperamide alone; Inline graphic, quinidine + loperamide; Inline graphic, HM30181 180 mg + loperamide