Figure 3.

Diagnostic plots for dextromethorphan (A), dextrorphan (B), 3-methoxymorphinan (C) and 3-hydroxymorphinan (D). The upper panel of these figures shows the visual predictive checks. In these visual predictive checks the dotted lines represent the 95% intervals of the observed concentrations vs. time, the solid line represents the observed median concentration vs. time and the shaded areas represent the 95% confidence interval for the model predicted concentrations. Also, the observed concentrations are plotted as open circles. The second panel from above shows the observed concentrations vs. the population predicted concentrations, the third panel from above shows the observed concentrations vs. the individual predicted concentrations and the bottom panel shows the normalized prediction distribution error vs. the population predicted concentrations