Figure 4.
Schematic representation of the population pharmacokinetic model of tamoxifen and endoxifen. The absorption phase is described with a rate constant (k12) and a lag time (tlag). The central tamoxifen compartment is in rapid equilibrium with the hypothetical metabolism compartment. Drug transfer between this metabolism compartment and the central tamoxifen compartment is described with the intercompartmental clearance parameter Q1. Metabolism of tamoxifen to endoxifen is described with the clearance parameter CLMET. Elimination of tamoxifen to other species is described with the clearance parameter CLTAM. The volume of distribution and clearance of endoxifen are fixed to known literature values