. 2014 Aug 21;78(3):610–618. doi: 10.1111/bcp.12362

Table 4.

Odds ratios of adverse events to treatment by infusion rate and presenting blood paracetamol

		All vomiting				All anaphylactoid
		Events / n	OR	95% CI	P	Events / n	OR	95% CI	P
Infusion rate¹
All patients (n = 835³)	15 min	73/321	1	–	–	29/321	1	–	–
All patients (n = 835³)	1 h	107/514	0.85	0.61, 1.20	0.368	55/514	1.22	0.75, 1.98	0.414
<100 mg l⁻¹ patients (n = 495)	15 min	46/185	1	–	–	26/185	1	–	–
<100 mg l⁻¹ patients (n = 495)	1 h	56/310	0.67	0.43, 1.05	0.084	47/310	1.10	0.66, 1.86	0.707
>100 mg l⁻¹ patients (n = 340)	15 min	27/136	1	–	–	3/136	1	–	–
>100 mg l⁻¹ patients (n = 340)	1 h	51/204	1.19	0.69, 2.04	0.527	8/204	2.15	0.54, 8.55	0.256
Paracetamol concentration²
All patients (n = 835³)	>100	78/340	1.09	0.78, 1.53	0.618	11/340	0.19	0.10, 0.37	<0.001
All patients (n = 835³)	<=100	102/495	1	–	–	73/495	1	–	–
15 min infusion (n = 321)	>100	27/136	0.77	0.45, 1.33	0.354	3/136	0.14	0.04, 0.48	<0.001
15 min infusion (n = 321)	<=100	46/185	1	–	–	26/185	1	–	–
1 h infusion (n = 514)	>100	51/204	1.37	0.88, 2.12	0.163	8/204	0.21	0.10, 0.47	<0.001
1 h infusion (n = 514)	<=100	56/310	1	–	–	47/310	1	–	–
Age⁴
All patients (n = 835³)	<35	111/412	1	–	–	45/423	1	–	–
All patients (n = 835³)	>=35	69/413	0.58	0.42, 0.82	0.002	39/414	0.82	0.51, 1.30	0.391
Gender⁵
All patients (n = 835³)	Female	125/507	1	–	–	51/507	1	–	–
All patients (n = 835³)	Male	55/328	0.66	0.46, 0.95	0.025	33/328	0.91	0.60, 1.51	0.688

1. Controlling for age, gender and presenting paracetamol concentration. 2. Controlling for age, gender and infusion rate. 3. one patient who had no data on blood paracetamol concentration was excluded. 4. Controlling for gender, infusion rate and presenting paracetamol concentration. 5. Controlling for gender, infusion rate and presenting blood paracetamol concentration.