Table 4.
Explorative analysis of OR of four times ULN CPK concentrations (compared with statin users with normal CPK concentrations) and of rhabdomyolysis (compared with statin users without rhabdomyolysis) stratified by concomitant drugs (results are shown for the drugs with the 20 highest ORs)
| >four times ULN CPK | Rhabdomyolysis | ||||||
|---|---|---|---|---|---|---|---|
| Crude OR (95% CI) | Crude P value | False discovery rate-adjusted P value | Crude OR (95% CI) | Crude P value | False discover rate-adjusted P value | ||
| Allopurinol | 2.01 (1.46, 2.75) | <0.001 | <0.001 | Bumetanide | 9.00 (1.50, 53.84) | 0.02 | 0.24 |
| Ezetimibe | 1.99 (1.27, 3.12) | 0.002 | 0.03 | Trimethoprim | 7.14 (1.57, 32.36) | 0.01 | 0.24 |
| Sildenafil citrate | 1.80 (1.17, 2.75) | 0.01 | 0.09 | Erythromycin | 6.00 (1.21, 29.73) | 0.03 | 0.29 |
| Hydrocortisone acetate/miconazole nitrate | 1.70 (1.00, 2.90) | 0.05 | 0.24 | Isopropyl myristate/liquid paraffin | 5.21 (1.03, 26.35) | 0.05 | 0.38 |
| Indapamide hemihydrate | 1.70 (1.14, 2.53) | 0.01 | 0.11 | Diazepam | 4.80 (1.29, 17.88) | 0.02 | 0.24 |
| Spironolactone | 1.68 (1.02, 2.77) | 0.04 | 0.22 | Spironolactone | 4.50 (1.01, 20.11) | 0.05 | 0.38 |
| Ipratropium bromide | 1.61 (0.95, 2.74) | 0.08 | 0.32 | Ferrous sulphate | 4.26 (1.28, 14.21) | 0.02 | 0.24 |
| Flucloxacillin sodium | 1.60 (1.08, 2.37) | 0.02 | 0.14 | Timolol maleate/dorzolamide hydrochloride | 4.00 (0.67, 23.94) | 0.13 | 0.76 |
| Emulsifying wax/liquid paraffin/white soft paraffin | 1.59 (0.95, 2.66) | 0.08 | 0.32 | Citalopram hydrobromide | 3.63 (1.40, 9.41) | 0.01 | 0.24 |
| Esomeprazole magnesium | 1.59 (0.95, 2.65) | 0.08 | 0.32 | Flucloxacillin sodium | 3.33 (1.07, 10.42) | 0.04 | 0.35 |
| Nicorandil | 1.55 (1.03, 2.33) | 0.04 | 0.22 | Cefalexin | 3.33 (0.54, 20.52) | 0.19 | 0.96 |
| Clopidogrel | 1.49 (1.17, 1.89) | <0.001 | 0.02 | Lactulose | 3.27 (1.21, 8.82) | 0.02 | 0.24 |
| Furosemide | 1.48 (1.19,1.85) | <0.001 | 0.01 | Betahistine dihydrochloride | 3.00 (0.55, 16.38) | 0.20 | 0.96 |
| Bisoprolol fumarate | 1.47 (1.18, 1.84) | <0.001 | 0.01 | Potassium bicarbonate/sodium alginate | 2.89 (0.83, 10.06) | 0.09 | 0.63 |
| Chloramphenicol | 1.44 (0.84, 2.44) | 0.18 | 0.59 | Dosulepin hydrochloride | 2.77 (0.44, 17.29) | 0.27 | 0.98 |
| Candesartan cilexetil | 1.41 (1.02, 1.96) | 0.04 | 0.22 | Rosiglitazone maleate | 2.77 (0.44, 17.29) | 0.27 | 0.98 |
| Diltiazem hydrochloride | 1.40 (1.02, 1.93) | 0.04 | 0.22 | Fluoxetine hydrochloride | 2.70 (0.67, 10.93) | 0.16 | 0.91 |
| Ramipril | 1.37 (1.15, 1.62) | <0.001 | 0.01 | Folic acid | 2.40 (0.47, 12.37) | 0.30 | 0.98 |
| Hydrocortisone | 1.37 (0.79, 2.37) | 0.27 | 0.67 | Ispaghula husk | 2.40 (0.47, 12.37) | 0.30 | 0.98 |
| Erythromycin | 1.37 (0.79, 2.37) | 0.27 | 0.67 | Lisinopril | 2.32 (1.09, 4.93) | 0.03 | 0.29 |