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. Author manuscript; available in PMC: 2015 Jan 15.
Published in final edited form as: Bioorg Med Chem. 2013 Nov 8;22(2):917–926. doi: 10.1016/j.bmc.2013.10.051

Scheme 2.

Scheme 2

Reagents and conditions: (a) i Magnesium, iodine, tetrahydrofuran, reflux; ii R-aldehyde, rt, 91%; (b) Triethylsilane, trifluoroacetic acid, dichloromethane, rt, 87%; (c) Borontribromide, dichloromethane, rt, 95%; (d) Tetrabutylammonium tribromide, chloroform, rt, 90%.