Table 1.

Summary of translation considerations for genomic medicine and primary care

Variable in translation	Primary care	Genomic medicine	ELSi considerations
Patient population	Families, communities, entire practices	Single, genetically unique patient	Respect for persons; relational decision making;
Technological capacities	Basic, minimal	Data-intensive sequencing machines	Lack of clinical validity and utility for CCCs; professional responsibilities, patient informed consent, disclosure of information, interpreting actionable genetic risks
Meeting health needs	Whole-person, generalist approaches to care; acuity to physical and psychosocial elements of health and wellbeing	Molecular conception of health and disease	Sociocultural and environmental understanding health; supra-genetic determinants of health
Health information	Electronic health record	Electronic health record	Data-intensive storage platforms needed with controlled access; privacy concerns
Graduate and post‐graduate training	Standardized	Under development	Professional responsibilities; lack of specific expertise
Standards of care	Established by professional medical bodies	Under development	Resource and time constraints; professional capacities; management of incidental findings; rights ‘not to know’
Health education	Frontline health educators for global factors of health and disease	Educators on genomic determinants of disease	Resource and time constraints; misunderstanding of genetic determinants of health