. Author manuscript; available in PMC: 2014 Nov 25.

Published in final edited form as: Sci Signal. 2014 Jul 22;7(335):ra69. doi: 10.1126/scisignal.2005431

Table 1.

Appearance of large-conductance (500-pS) channel, ATP release, or dye uptake in response to various stimuli. CHO, Chinese hamster ovary; HEK 293, human embryonic kidney 293; nd, not determined.

Physiological stimulation of Panx1	Large channel (~500 pS)	ATP release or dye uptake	cell type	references
Mechanical stress	yes	yes	oocyte, erythrocyte	(1, 2)
Low oxygen	yes	yes	erythrocyte, neuron	(2, 20)
Intracellular Ca²⁺	yes	yes	oocyte	(7)
ATP activating purinergic receptor signaling	nd	yes	oocyte	(7, 8)
Glutamate activating NMDA receptor signaling	nd	yes	neuron	(39)
Panx1 activated experimentally or under pathological condition
Extracellular K⁺	yes	yes	oocyte, erythrocyte, astrocyte	(1, 9, 12, 13, 30, 50)
Caspase 3 cleavage	nd	yes	Jurkat cells	(27)
Exclusively voltage-gated Panx1
	no, 50–70 pS channel	no	HEK 293 cells, CHO cells, oocyte	(17, 18), present study