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. 2014 Aug 12;171(17):4051–4061. doi: 10.1111/bph.12755

Figure 1.

Figure 1

Isolation of the novel TAZ modulators, TM-53 and TM-54. (A, B) COS7 cells were transfected with GFP-TAZ and RFP-H2B and subsequently treated with different doses of TM-53 for 2 h under normal (isotonic) and low salt (hypotonic) conditions. Representative cell images were captured on a BD Pathway Bioimager system (A). The percentage of cells expressing TAZ in the nucleus was determined by counting at least 500 GFP-positive and RFP-positive cells from three independent experiments (B). (C) Chemical structures of TM-53 and TM-54.