Table 1.
Potencies and maximal effects of natural tachykinins and their PWT derivatives in calcium mobilization experiments performed in CHO cells expressing human NK receptors
| NK1 | NK2 | NK3 | ||||
|---|---|---|---|---|---|---|
| pEC50 (CL95%) | Emax | pEC50 (CL95%) | Emax | pEC50 (CL95%) | Emax | |
| SP | 10.40 (9.93–10.87) | 109 ± 8% | 7.18 (6.99–7.37) | 178 ± 19% | 7.15 (7.01–7.29) | 217 ± 30% |
| PWT2-SP | 9.02 (8.85–9.19) | 95 ± 2% | 6.17 (5.62–6.72) | 168 ± 11% | 7.15 (6.90–7.45) | 190 ± 21% |
| NKA | 9.70 (9.32–10.08) | 108 ± 10% | 9.32 (9.05–9.58) | 174 ± 11% | 7.39 (6.81–7.97) | 222 ± 21% |
| PWT2-NKA | 8.44 (7.79–9.09) | 93 ± 10% | 7.70 (7.06–8.36) | 183 ± 10% | 6.63 (6.03–7.23) | 204 ± 18% |
| NKB | 8.34 (8.13–8.55) | 99 ± 10% | 7.15 (6.81–7.49) | 177 ± 9% | 7.96 (7.62–8.30) | 207 ± 18% |
| PWT2-NKB | 8.03 (7.82–8.24) | 88 ± 11% | 6.73 (6.22–7.24) | 176 ± 13% | 7.82 (7.25–8.39) | 199 ± 17% |
Data are mean ± SEM of at least four experiments performed in duplicate. CL95%, 95% confidence limits.