Table I.

TEM-1 β-Lactamase Contact Residues with BLIP and BLIP-II

TEM-1 residues	BLIP	BLIP-II
Gln99	+a	+
Asn100	+	+
Leu102	+	+
Val103	+	−
Glu104	+	+
Tyr105	+	+
Ser106	+	−
Pro107	+	+
Glu110	+	+
Lys111	+	+
His112	+	−
Leu113	−	+
Met129	+	+
Ser130	+	−
Pro167	+	−
Glu168	+	−
Asn170	+	−
Lys215	+	−
Val216	+	+
Lys234	+	−
Ser235	+	−
Ala237	+	+
Gly238	+	−
Arg244	+	−
Met272	+	+
Asp273	−	+

^a+/− Indicates that the TEM-1 residue is/is not interacting with either BLIP or BLIP-II. The contact residues were defined based on X-ray crystal structures of the BLIP-TEM-1 and BLIP-II-TEM-1 β-lactamase structures.^16,19