Table 2.

The functions and involved pathways of miR-145 targets

Target gene	Involved pathway	Cancer types	References
IRS-1, IGF-IR	Proliferation	Colon cancer, hepatocarcinoma	85,87–89,164
EGFR, NUDT1	Proliferation	NSCLC	90
ILK	Proliferation	Bladder cancer	93
DFF45	Apoptosis	Colon cancer	94
CBFB, PPP3CA and CLINT1	Apoptosis	Bladder cancer	95
TNFSF10	Apoptosis	Prostate cancer	97
SOCS7	Apoptosis	Bladder cancer	98
c-Myc	Proliferation, apoptosis, invasion	Colon cancer, NSCLC, ovarian cancer, breast cancer, oesophageal and oral squamous cell carcinoma	66,99,101–104
FLI1, EWS-FLI1, Ets1(ERG),	Proliferation, apoptosis, invasion	Colon cancer, prostate cancer, gastric cancer, Ewing's sarcoma	106–108,110
RTKN	Proliferation	Breast cancer	112
YES, STAT1	Proliferation	Colon cancer	113
HDAC2	Proliferation	Hepatocarcinoma	114
PAI-1	Unknown	Bladder cancer	115
MUC1	Invasion	Breast cancer, ovarian cancer	121–123
FSCN1	Invasion	Bladder cancer, oesophageal squamous cell carcinoma, prostate cancer, breast cancer, melanoma	124–130
JAM-A	Invasion	Breast cancer	129
SWAP70	Invasion	Prostate cancer	131
HEF1/NEDD9	Invasion	Glioblastoma, prostate cancer, renal cell carcinoma	134–136
N-cadherin	EMT, invasion	Gastric cancer	137
ADD3	Invasion	Glioma	138
ADAM17	Proliferation, invasion	Renal cell carcinoma	140,141
SOX9	Proliferation, invasion, CSCs	Glioma, head and neck cancer	138,142
CTGF	Invasion	Glioma	143
Catenin delta-1	Proliferation, cell cycle, invasion	Colon cancer	144
PAK4	Proliferation, invasion	Colon cancer	145
OCT4	Differentiation and CSCs	Human embryonic stem cells, hepatocarcinoma, breast cancer, NSCLC, endometrial adenocarcinoma, skin keratinocyte	41,93,95,153,155–157,167
SOX2	Differentiation and CSCs	Human embryonic stem cells, glioblastoma	153,154
KLF4	Differentiation and CSCs	Human embryonic stem cells	153
VEGF	Angiogensis, invasion	Osteosarcoma	161
p70S6K1	Proliferation, angiogenesis, invasion	Colon cancer, ovarian cancer	123,162
N-RAS	Angiogenesis	Breast cancer, colorectal cancer	163,164
ICP4	Virus	Prostate cancer	166