Table 2.

List of neuronal porosome proteins containing various lipid-binding domains

Lipid-binding domains	Known proteins containing specific lipid binding domains	Lipids binding specific protein domains	Porosome proteins with lipid-binding domains
C1 (Cystein-rich C1 domains)	PKC isoforms -Diacylglycerol Kinase -c-Raf Ser/Thr Kinase -n-Chimaerin Rac-GTPase Activating Protein	Diacylglycerol or phorbol esters
C2 (Calcium-dependant lipid-binding domain)	-cPLA2 -Phosphatidylinositol 3- kinase (PI3K) -Tensin phosphatase -Synaptotagmin 1	Wide range of lipid selectivity including PC, PS	Synaptotagmin 1
PH (Pleckstrin Homology Domain)	Phospholipase C-δ, mSos1, RasGAP, Tsk, pleckstrin, Btk, Grp1, Akt, DAPP1, TAPP1, Spectrin beta, Dystrophin	PI-(4,5)-P2; PI-(3,4,5)-P3 PI-(3,5)-P2; Ins(1,4,5)P3	GAP, Spectrin beta, Dystrophin (central rod made of 24 spectrin-like repeats)
FYVE (Fab-1, YGL023, Vps27 and EEA1 domain is a cysteine-rich Zn2+-binding domain of 60–70 AA)	-EEA1 Early Endosome Antigen -Hrs Putative ATPase -SARA (Smad Anchor for Receptor Activation) -FENS1	PI(3)P
PX (Phox homology domain is ∼120 AA)	Found in more than 250 proteins, including the p40phox and p47phox components of the NADPH oxidase complex, sorting nexins, phospholipases D1 and 2 and the kinases PI3K and CISK.	PI(3)P; PI-(3,4)-P2 PI-(3,4,5)-P3; PI-(3,5)-P2 PI(5)P
ENTH (Epsin N-terminal homology domain)	-CLINT1 (clathrin interactor)	PI-(4,5)-P2 PI(1,4,5)P3
ANTH (AP180 N-terminal homology domain)		PI-(4,5)-P2
BAR (Bin/Amphiphysin/Rvs)	Endophilins, Dynamin, Nexins, Amphiphysin, RhoGAPs, RhoGEF	Bind lipid membrane with high curvature	GAP, Dynamin Intersectin 1 (Rho family GEF)
FERM (Named after four proteins from which it was originally described: Band 4.1 (F), Ezrin >(E), Radixin (R) and Moesin (M))	Talin, Radixin, ERM, Willin, Moesin, PTP1, Radixin/Ezrin, JAK123	IP3, PI(3)P; PI(4)P; PI(5)P; PI-(4,5)P2; PI-(1,4,5)P3
Tubby domains	Binds basic protein pockets	PIP2