Table 1.

Changes of different parameters of mice after 8 weeks of treatment of vehicle, STZ, STZ+valsartan (10 or 20 mg/kg), and valsartan (20 mg/kg)

Treatment	Number of animals	Body weight (g)	Plasma glucose (mg/dl)	Plasma insulin (ng/ml)	Plasma tissue factor activity (pM)
Vehicle	7	29.6 ± 2.4	149.3 ± 13.9	0.88 ± 0.24	7.3 ± 0.9
STZ	10	23.8 ± 1.2**	336.3 ± 54.5**	0.13 ± 0.02**	11.0 ± 1.4**
STZ+Valsartan (10 mg/kg)	10	23.9 ± 1.2	298.2 ± 88.1	0.17 ± 0.10	11.1 ± 2.5
STZ+Valsartan (20 mg/kg)	10	24.2 ± 1.2	210.1 ± 61.4††	0.49 ± 0.10††	9.2 ± 1.6†
Valsartan (20 mg/kg)	7	27.7 ± 1.2	145.4 ± 35.7	0.68 ± 0.13	9.0 ± 1.1

Value are means ± SEM.

**P < 0.01 versus Vehicle.

†P < 0.05,

††P < 0.01 versus STZ, respectively.