Table 1.
Influence of protease inhibitors on GP shedding
| Inhibitor | Inhibitory effect on GP1,2Δ shedding |
|---|---|
| TAPI-I (50 μM) | + |
| 1,10-Phenanthroline (1 mM)a | + |
| EDTA (5 mM) | − |
| EGTA (5 mM) | − |
| Phosporamidon | −b |
| α-1-Antichymotrypsin (4 μM) | − |
| Captopril (10 μM) | − |
| BB2516 (500 nM) | + |
| GM 6001 (5 μM) | + |
| TIMP-1, -2, and -4 (200 nM) | − |
| TIMP-3 | −b |
| MMP-2 inhibitor I (100 μM) | − |
| MMP-3 inhibitor II (50 μM) | + |
| MMP-8 inhibitor I (5 μM) | + |
| CGS-27023A (25 μM) |
+ |
| +Inhibition of ⩾50% at the indicated inhibitor concentration. | |
| −No inhibition at the indicated inhibitor concentration. | |
| aInhibition by 1,10-phenanthroline is reversible by equimolar Zn2+ addition. | |
| bInhibitory effect less than 50% and no dependence on inhibitor concentration. | |