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. 2014 Aug 23;11:148. doi: 10.1186/s12974-014-0148-9

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© Yang et al.; licensee BioMed Central Ltd. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Confocal images showing the induction of CNPase expression at 7 days after middle cerebral artery occlusion and fluid perfusion injury. CNPase expression (Ab, Ae, and Bb, Be; red) in FITC-lectin labeled microglia (Aa, Ad, and Ba, Bd; green,) and DAPI (blue) in the ischemic cortex (A) and ipsilateral injury cerebrum (B) is hardly detected in the microglia in the sham group. A marked increase in CNPase expression is observed in FITC-lectin-labeled microglia both in the middle cerebral artery occlusion (MCAO) infarct area and fluid perfusion injury (FPI) site when compared to the sham group. Note also that the activated microglial cells are amoeboidic in appearance. Scale bars = 20 μm (A and B). CNPase, 2′,3′-cyclic nucleotide 3′-phosphodiesterase; DAPI, 4′,6- diamidino-2-phenylindole.