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. 2014 Aug 23;11:148. doi: 10.1186/s12974-014-0148-9

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© Yang et al.; licensee BioMed Central Ltd. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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CNPase knockdown on cell cycle progression in BV-2 cells. (A) Representative DNA histogram plots from an individual experiment showing control small interfering RNA (siRNA) and CNPase siRNA transfected groups with and without lipopolysaccharide (LPS) treatment. (B) Percentage of total cells in each phase of cell cycle. CNPase knockdown arrested the cells in the G1 phase with a corresponding decrease in the percentage of cells entering into the S + G2/M phase. *P < 0.05 compared with controls by unpaired t-test, from three independent experiments. CNPase, 2′,3′-cyclic nucleotide 3′-phosphodiesterase.